The Annotation Clearinghouse offers a mapping of genes which are identical in sequence except for the start region (due to differences in start calling).
Set FIG function to
3-ketoacyl-CoA thiolase (EC 2.3.1.16)
5/26/2005
master:MatthewH_UFL
Assigning function Acetyl-CoA acetyltransferase (EC 2.3.1.9) based on installation of subsystem Anaerobic_benzoate_metabolism
5/26/2005
MatthewH_UFL
Set FIG function to
Acetyl-CoA acetyltransferase (EC 2.3.1.9)
8/8/2005
OlgaZ
Set FIG function to
3-ketoacyl-CoA thiolase (EC 2.3.1.16); Acetyl-CoA acetyltransferase (EC 2.3.1.9)
10/6/2005
OlgaV
Set FIG function to
3-ketoacyl-CoA thiolase (EC 2.3.1.16); Acetyl-CoA acetyltransferase (EC 2.3.1.9)
6/7/2006
OlgaV
Set FIG function to
3-ketoacyl-CoA thiolase (EC 2.3.1.16); Acetyl-CoA acetyltransferase (EC 2.3.1.9)
5/28/2008
OlgaZ
Set function to
Acetyl-CoA acetyltransferase (EC 2.3.1.9)
11/9/2008
OlgaV
Set FIG function to
3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)
This feature is part of a subsystem
In Isoleucine degradation its role is 3-ketoacyl-CoA thiolase (EC 2.3.1.16). However, this subsystem has been classified as not being functional in this organism.
In Glyoxylate bypass its role is Acetyl-CoA acetyltransferase (EC 2.3.1.9). However, this subsystem has been classified as not being functional in this organism.
In Serine-glyoxylate cycle its role is 3-ketoacyl-CoA thiolase (EC 2.3.1.16). However, this subsystem has been classified as not being functional in this organism.
In Butanol Biosynthesis its role is Acetyl-CoA acetyltransferase (EC 2.3.1.9). However, the functionality of this subsystem has not yet been classified for this organism.
In n-Phenylalkanoic acid degradation its role is 3-ketoacyl-CoA thiolase (EC 2.3.1.16). However, this subsystem has been classified as not being functional in this organism.
Reasons for Current Assignment
The encoded protein plays multiple roles which are implemented by the same domain with a broad
specificity. The roles are "3-ketoacyl-CoA thiolase (EC 2.3.1.16)" and "Acetyl-CoA acetyltransferase
(EC 2.3.1.9)". The protein occurs in 3 subsystems: "Acetyl-CoA fermentation to Butyrate",
"Isoprenoid Biosynthesis", and "Polyhydroxybutyrate metabolism". In "Acetyl-CoA fermentation to
Butyrate", it occurs in close proximity on the chromosome with 4 other genes from the same
subsystem. In "Polyhydroxybutyrate metabolism", it occurs in close proximity on the chromosome with
2 other genes from the same subsystem. The function of genes having the same functional roles have
been described in Clostridium acetobutylicum (11075929, 1685080, 7867955), Saccharomyces cerevisiae (5571829, 7989303, 8754796), Homo sapiens (15242332, 8241273) and Sinorhizobium meliloti (7582015). These are homologous proteins which implement the same function.
Compare Regions
The chromosomal region of the focus gene (top) is compared with four similar organisms. The graphic is centered on the focus gene, which is red and numbered 1. Sets of genes with similar sequence are grouped with the same number and color. Genes whose relative position is conserved in at least four other species are functionally coupled and share gray background boxes. The size of the region and the number of genomes may be reset. Click on any arrow in the display to refocus the comparison on that gene. The focus gene always points to the right, even if it is located on the minus strand.
Topic revision: r6 - 02 Mar 2009 - 22:06:54 - Bruce Parrello
